Hi Colin
Do you know how to set up save uploads?
it depends on how you system is configured.
I would create a 2 save uploads using the Get contact and Get leads external calls.
Add the field that holds the unsub information for to the list of fields to chose from.
Set the filter to select only contact who are unsubs and set to run since the last time it.
The uploads actions will include adding to a program where you and unsub from all or or campaigns.
See if support can help. It is a bit tricky.
Good Luck!